The present study was thus designed to monitor and explore the incidence of ADRs to various antiretroviral therapy (ART) regimens in a tertiary care ART setup. Antiretroviral therapy (ART) has reduced HIV morbidity and mortality worldwide but has many adverse effects. These adverse drug reactions (ADRs) lead to discontinuations, disease progression or treatment failure. The purpose of this study was to evaluate the incidence of adverse effects in patients using Antiretroviral Therapy (ART) in HIV-infected patients. This is a prospective observational study eligible for all the patients receiving ART therapy that were monitored at ART center between 2016 may-2018 mar conducted at Sri Venkateswara Ramnarayanruya Government General Hospital (SVRRGGH), Tirupati. Out of 510 patients 120 ADRs has been observed. Females were more represented with 75%. The drug regimen which represented more ADRs were found to be ZLN (54.16%) followed by TLE (44.16%) and LR/TL (1.66%). Highest ADR in system wise classification was found in CNS (29.16%) followed by GI (25%), dermatology (16.66%) hematology (15%), metabolic (12.5%) and renal system (1.66%). Adverse effects of antiretrovirals are frequent and could be life-threatening in short and long terms. Regular follow-up of patients receiving these triple therapies and the associated complications, is essential. Thus, the findings of our study suggest that the treating clinicians must focus on early detection and prevention of ADRs in HIV infected patients receiving ART that will help to modify their drug regimens and to provide better adherence to antiretroviral therapy.
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